The Age-Related Macular Degeneration (AMD)-Preventing Mechanism of Natural Products

Age-related macular degeneration (AMD) is related to central visual loss in elderly people and, based on the increment percentage of aging population, number suffering from AMD could increase. initiated by retinal pigment epithelium (RPE) cell death, finally leading neovascularization macula lutea. an uncurable disease, but symptom can be suppressed. The current therapy classified into four types: device-based treatment, anti-inflammatory drug anti-vascular endothelial growth factor and natural product treatment. All these therapies have adverse effects, however early used with products has several advantages, as it prevent RPE apoptosis safe doses. Cell death (apoptosis) caused various factors, such oxidative stress, inflammation, carbonyl a deficiency essential components for cells, stress. Some anti-oxidative anti-inflammation and/or anti-carbonylation effects. preventive mechanism varies, some activating one or more anti-apoptotic pathways, Nrf2/HO-1 pathway, anti-inflammasome anti-carbonyl pathway. As candidates effectively inhibit they potential developed drugs preventing (dry) AMD.